Drug-induced lichenoid reaction

Drug-induced lichenoid reactions (also known as "Lichenoid drug eruption"[1] and "Drug-induced lichen planus") are skin eruptions that occur after ingestion, contact, or inhalation of certain chemicals, with the most common inducers being gold salts, beta blockers, antimalarials, thiazide diuretics, furosemide, spironolactone, and penicillamine.[2]:470 As well as systemic side effects of hypoglycaemic drugs such as Metformin. [3]:160

Restated, lichenoid drug reactions occur as type IV (delayed) allergic reactions to medications for high blood pressure, heart disease and arthritis. These lichenoid reactions are referred to as lichenoid mucositis (of the mucosa) or dermatitis (of the skin). Allergic reactions to amalgam (metal alloys) dental restorations (fillings) may contribute to the oral lesions identical, both clinically and histologically, to oral lichen planus lesions, and a systematic review found that many of the lesions resolved after the restorations were replaced.[4]

See also

references

  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  2. ^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0071380760.
  3. ^ Edward W. Odell. (2010). "Clinical Problem Solving in Dentistry". (3rd ed.).
  4. ^ Issa Y, Brunton PA, Glenny AM, Duxbury AJ (November 2004). "Healing of oral lichenoid lesions after replacing amalgam restorations: a systematic review". Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98 (5): 553–65. doi:10.1016/j.tripleo.2003.12.027. PMID 15529127.